Contract medical device injection molder and manufacturer West Pharmaceutical Services Inc. is adding clean room and injection molding capacity to help it meet demand for one of its customer's syringe systems, the Daikyo Crystal Zenith syringe system. The systems are molded using Daikyo's proprietary Crystal Zenith-brand cyclic olefin polymer.
West is adding the capacity to its headquarters facility in Scottsdale, AZ. The contract molder / manufacturer and its customer Daikyo have worked together on this syringe system for the past few years and market it as a slightly less costly in the short term, but immeasurably less expensive long-tern replacement for glass syringe systems. The slightly higher short-term costs are countered by the reduction of risk (of breakage or delamination) that pharmaceutical and biopharmaceutical companies assume when they opts for glass syringes.
Auto-injector systems traditionally use 1-ml long glass prefilled syringes. These systems are the established standard but have limitations, including the potential for breakage and the potential for silicone oil and tungsten residues to induce protein aggregation in prefilled syringes. Silicone oil is used to increase lubricity in glass syringe systems. West argues that this oil can be distributed unevenly, leaving surface areas with insufficient lubrication. This will greatly increase the force required to operate the auto-injector and may lead to delivery of a partial dose to the patient....